Issue Summary
Below are the topics covered in the most recent issues of Staying Current: Formulation of Biopharmaceuticals. Please visit Staying Current and select an option, if you'd like to subscribe.
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Agitation-Induced Aggregation of Proteins
Self-Association of Fc-Fusion Proteins
Coarse-Grained Simulations of mAbs
Relaxation in Freeze-Dried Formulations
Shaking of Freeze-Dried Formulations
Ion Binding and mAb Aggregation
Poly(Glu) Derivatives as Viscosity Reducers
Osmolality of High Concentrations mAbs
Taurine as a Stabilizer of mAbs
Nano-Osmolytes as Stabilizers
Use of ILs and DES as Stabilizers
Monitoring Visible Particles in Parenterals
wNMR Characterization of HC mAbs
pH Effects on HCP Polysorbate Degradation
Heat Inactivation to Slow Polysorbate Loss
Aggregation Kinetics of PTH(1-84)
Fractionation of Protein Particulates
Potency and Stability of Charge Variants
Flow-Induced Aggregation Assay for mAbs
Salt Effects on Protein LLPS
Forced Degradation Studies: Comparability
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Injectable Hydrogel Particles for mAbs
Depot s.c. Injections of Antisense Products
Fill-Finish Operation for Biologics
Prediction of mAb Viscosity Behavior
Barriers to Inhalation Therapy Using mAbs
Dry Powder Inhalation of siRNA
Hydration and Protein Stability in DES
Effects of DES on Enzymes
Phospholipids to Inhibit Protein Aggregation
Aggregation Slowed by Osmolytes
Developing Novel Aflibercept Formulations
PS20 Degradation Affects mAb Formulation
Osmolyte-Induced Protein Stabilization
Polyelectrolyte Stabilization of LDH
Asn Deamidation at Asn-Trp Site in a ADC
Modeling Deamidation in Solution
Approaches for s.c. Delivery of Proteins
Effects of Vibration from Drone Transport
Shear Stress on Protein Pharmaceuticals
Stabilization of Proteins by Saccharides
Development and Manufacture of Biologics
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Interface-Mediated Protein Aggregation
Cyclodextrins in Drug Delivery
Complexation with Sulfated Cyclodextrins
Preservatives and Interactions with mAbs
Aggregation Pathways for Antibodies
Protein Stabilization by Sugars
Arg and Arg Ester as Possible Stabilizers
Stabilization Strategies for Protein Drugs
Reversible Protein Complexation
Coacervation of Protein Complexes
Predicting Biotransformation
PTMs and Stable Dried Protein Powders
Predictions of mAb Developability
Review of mAb Developability
Lyophilization of AAV8
Microwave-Assisted Freeze-Drying
Developable Antibody-Based Products
Surfactants in mAb Cell Culture Medium
Delivery of Polypeptides to the Eye
Deep Learning in Antibody Development
Nanofiltration of mAbs
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Advances in Lyo Cycle Development
mAb PPIs and Viscosity Behavior
NMR Analysis of Thermally Stressed mAbs
Aggregation during Peristaltic Pumping
Use of QbD in Lyo Development
Simulations of mAb Self-Association
Arginine in Protein Formulations
Effects of Charged Amino Acids
Subvisible Particle Image Analysis
Oxidation of Polysorbates
kD Values and Predicting Viscosity
Interfacial Pressure and Long-Term Stability
Deamidation/Clipping in LC of a mAb
PEG Precipitation and Colloidal Stability
Devitrification of Lyoprotectants
Occurrence of Ser-Lys Crosslink in a mAb
Optimization of Flow Imaging Microscopy
mAb In-Use Stability with Degraded PS 20
mAb Aggregation in Cell Culture
α Relaxation of Long-Term mAb Stability
Annealing and Shrinkage of Dried Sugars
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Predicting Aggregation Using ILs Alternatives to Polysorbates
Preclinical Studies: Caffeine as an Excipient
Protein Stabilization during Manufacturing
Review of Insulin Aggregation
Instabilities during Manufacturing
Prediction of pH-Dependent Solubility
Sugars Inhibit Insulin Aggregation
Biological Diversity of Trehalose
Trehalose Effects in Synuclein Fibrillation
Sugars as Cryoprotectants
Stabilization of Irisin by Trehalose
Review of Noncovalent PEGylation
Disaccharide Stabilization of hGH
Injectable Devices for Protein Delivery
Protein Stabilization by Disaccharides
Trehalose as a Lyoprotectant for Phages
Protein Solubility Optimization
Viscosity Predictions from MD Simulations
pH/salt Effects on Self-Association of mAbs
Interfacial Particle Formation with mAbs
Delivery of Biologics to the Colon
Effects of Crowding by PEG
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Alternative Surfactants for Biologics
Biosurfactants in Pharmaceutical Products
Cyclodextrins as Drug Stabilizers
Modeling Viscosity Behavior of mAbs
Poloxamers in Nanomedicine
Polymeric in situ Forming Depots
Long-Acting Microneedle Formulations
Intermolecular Interactions in an ADC
Deamidation of Pertuzumab
Formulation of AAVs
Oxidation of Polysorbates
Arg/HP β CD Deep Eutectic Solvents
Formulation of Non-Invasive Vaccines
Trisulfides in Multi-Specific mAbs
Monitoring Aggregation using CE-SDS
Silicone Oil-Induced Aggregation
Controlling Glycation with Cyclodextrins
Protein Amyloid Aggregates
Particulate Impurities in AAVs
Protein Stabilization by Aptamers
Controlling Deamidation of Capsid Protein
Formulation of Oncolytic Viruses
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Stabilization of Proteins by Sugars
Deamidation Promoting Aggregation
Chemical Chaperones as Stabilizers
Chemical Chaperones as Stabilizers
Particle Formation in mAb Infusions
In-Use/Compatibility Studies for Biologics
Stability Predictions of Biopharmaceuticals
Solid-State Lysozyme-Sucrose Interactions
Lyo Cycle Design for HC Proteins
Lyo Protein-Specific Excipient Effects
Solid mAb Formulation in an Auto-Injector
Reformulation of a mAb
Determinants of Viscosity in HC mAbs
Amyloid Aggregation and LLPS
De-/Stabilization of BSA by Sugars
Polysorbate Degradation Kinetics
Poloxamer 188 and F/T Damage
Effect of Freezing Citrate Solutions
Container Effects on PS 80 Oxidation
Oxidative Fragmentation of an IgG1 mAb
Raman Analysis of Acidic HC Formulations
In-Use Studies on Pertuzumab
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Review of HC mAb Formulations
Review of Nucleic Acid Therapeutics
Commercial Antibody Formulations
Approved Oligonucleotide Therapeutics
Polypeptide Instability in Polymer Systems
Acidic Variants of mAbs Induced by MCO
Succinimide Formation in CDR of a mAb
mAb Aggregation Mechanisms
Alternative Surfactant and Bioprocessing
Factors Affecting Silicone Oil Migration
Reversible Self-Association of mAbs
Additive Effects on Antibody Stability
Sugar Effects on Protein Fibrillation
Surface Activity and Interfacial Stability
Behavior of a mAb at Air-Water Interface
Tribofilm Behavior of BSA with Metal Ions
Characterizing Protein Lyo Formulations
Microstructure of Lyophiles
Oxidation-Induced Aggregation of a mAb
Microwave-Assisted Freeze-Dryin
Downstream Processing of mAbs
IL-Based Processing and Formulation
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PPIs and Viscosity Behavior of mAbs
Developability of HC mAb Formulations
Properties of Marketed mAb-Based Products
Cake Appearance of Lyophilized Proteins
Inhibition of Fibrillation by 18-crown-6
Chemical and Physical Stability of Peptides
Self-Association and Viscosity of mAbs
Protein Photooxidation under Visible Light
Spray Freeze Drying (2)
Predicting the Shelf-Life of Lyophiles
Crystallization in Lyo Protein Samples
Water Dynamics and Protein Stability
mAb Stability in Prefilled Syringes
Deep Eutectic Solvents for IgGs
mAb-Excipient Interactions by NMR
Machine Learning and Viscosity Behavior
Preservatives in Polypeptide Formulations
Aggregation of Calcitonin Variants
Competitive Adsorption of mAb/PS 80
Chemometrics in Protein Formulation
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Stability of mAbs in Ambient Light
Sensitivity and Variability of MFI
Inherent Particles in Biologicals
Particle Formation by Flow Cytometry
Stabilized HC mAb Formulation
Review of TFF Operations
Multi-Instrument MFI Evaluation
Terminal Sterilization of Biologicals
Pulse Radiolysis and Oxidative Crosslinking
Unfolding and Aggregation of LCs
Predicting Protein Solubility
Optimization of Protein Solubility
Developability Studies of mAbs (2)
Concentration-Dependent Fab Stability
Effects of Excipients on Viscosity
MCO and Acidic Charge Variants in a mAb
Polysorbates and IgG1 Particle Formation
Relationship between PPIs and LLPS
B22 Values and LLPS
Surface-Mediated Aggregation
Thermal Aggregation of hGH
Developability Risks for mAbs
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Protective Effects of Sugars on Dry Proteins
Stability of Freeze-Dried IgY
Morphology of Sucrose/Mannitol Mixtures
Nebulization In-Use Studies
SC Depot Behavior of Peptide Conjugate
Atomization Effects on Spray Freeze-Drying
Mannitol-Based Antibody Lyo Formulations
ssNMR Analysis of Lyo mAb Formulations
Stabilization of mRNA Products
Polysaccharides to Stabilize Peptides
Immunogenicity of Stressed Adalimumab
Stability of an Acidic mAb
SVPs by Holographic Video Microscopy
Forced Degradation Studies of Peptides
Formulation Strategies for Peptides
Immunogenicity of Protein Aggregates
Developability Assessment of mAbs
Chemical Chaperone Effects on Aggregation
Excipient Effects on Stability of BSA
Improving the Properties of Peptide Drugs
Long-Term Stability of Infliximabs
Excipients of BMP-2 Refolding
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Studying Protein Aggregation
Surface-Induced Aggregation
Modeling PPIs and Viscosity Behavior
In-Vial Detection of Protein Unfolding
Sustained s.c. Release of scFv
Oxidation of PS 80 in Stainless Steel
Analytical Workflow and Developability
Developability Assessment of mAbs
Is There a Superior Fraction of PS 20?
Peristaltic Tubing Effects on TFF Operation
Deep Eutectic Solvents to Stabilize IgGs
Measuring Self-Association of mAbs
Predicting mAb Stability Profiles
Predicting mAb Behavior during TFF
Dynamics in Predicting mAb Properties
Polymeric Excipient and Colloidal Stability
Measuring the Stability of ADCs
Conformational Changes and LLPS
Predicting mAb Viscosity Behavior
Visible Particle Formation and Silicone Oil
Stabilization by PEGs of Different Sizes
PLGA Depots for Leuprolide Acetate