Advancing Biopharmaceutical Formulation & Assay Development
Tailored scientific support that accelerates formulation success.
With 20+ years of global experience, we partner with biotech innovators to optimize, stabilize, and characterize therapeutics for clinical and commercial success.
Recent News & Highlights
Upcoming Short Course
Formulation & Stabilization of Biotherapeutics Professional Short Course
April 27-30, 2026 | Virtual Format
Legacy BioDesign is pleased to announce our upcoming short course on protein and peptide formulation and stabilization. This comprehensive four-day program draws on our two decades of experience in biopharmaceutical formulation development and our extensive work with clients across nearly 20 countries.
Recent Publications
“Chemometric evaluation of key residues affecting the stability of cold shock proteins”, Jack E. Buckley, Nathaniel J. Zbacnik, Charles S. Henry, and Mark Cornell Manning, BBA - Proteins and Proteomics 2026, 1874: 141126.
“Characterization and Preformulation Studies of Human Mesencephalic Astrocyte-Derived Neurotropic Factor (hMANF)”, Robert W. Payne, Tiansheng Li, Ryan R. Manning, Glenn A. Wilson, Charles S. Henry, and Mark Cornell Manning, ACS Chemical Neuroscience 2025, 16: 1442-1453.
“The Role of Phase Separation and Local Mobility in the Stabilization of a Lyophilized IgG2 Formulation”, Ashley Lay-Fortenbery, Ryan E. Holcomb, Charles S. Henry, Mark Cornell Manning, and Eric J. Munson, AAPS PharmSciTech 2024, 25: 268.
Your Trusted Partner in Biopharmaceutical Formulation and Assay Development
At Legacy BioDesign LLC, we specialize in the formulation and assay development of biopharmaceuticals. We are committed to your success, as we have been for the past twenty years, serving clients around the globe. Our team has a wealth of experience and we will provide the highest quality support for your formulation projects.
Our Expertise
Protein & Peptide Formulation
Formulation design and optimization for protein and peptide therapeutics, with a focus on stability, clinical relevance and manufacturability.
Analytical Capabilities & Assay Development
Custom analytical method development to support characterization, stability studies, and release testing - ensuring you have the data needed for confident formulation decisions.
Biophysical Characterization
In-depth biophysical analysis to reveal how your therapeutic behaves under various conditions, guiding formulation strategies and demonstrating comparability.
Chemometrics & Developability
Advanced data analysis and statistical modeling to identify optimal formulation candidates, predict stability outcomes, and accelerate developability assessments.
Formulation of Other Therapeutics
Specialized formulation support beyond proteins and peptides, including oligonucleotides, antibody-drug conjugates (ADCs), vaccines, and emerging therapeutic modalities.
50+
US Patents Supported
Why Choose Legacy BioDesign LLC
20+
Years of Experience
Global Client Partnerships
Multiple Drugs in Clinical Use