Publications

“Application of Formulation Principles to Stability Issues Encountered during Analysis, Processing and Manufacturing of Drug Substance and Drug Product Protein Therapeutics”, Samadhi Vitharana, Joshua M. Stillahn, Derrick S. Katayama, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2023, 112: 2724-2751.

“Characterization of Oligomer Species in Surfactant Protein-D (SP-D) using AF4-MALLS”, Ryan R. Manning, Ryan E. Holcomb, Derrick S. Katayama, Giovanni M. Pauletti, Shawn N. Grant, Jan S. Rosenbaum, and Mark Cornell Manning, Current Protein and Peptide Science 2022, 23: 862-873.

“Chemometric Study of the Relative Aggregation Rate of Position 19 Mutants of Aβ(1-42)”, Nathaniel J. Zbacnik, Charles S. Henry, and Mark Cornell Manning, Current Protein and Peptide Science 2022, 23: 52-60.

“Analysis of Peptides using Asymmetrical Flow Field-Flow Fractionation”, Ryan R. Manning, Ryan E. Holcomb, Derrick S. Katayama, Robert W. Payne, Joshua M. Stillahn, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2021, 110: 3969-3972.

“A Chemometric Approach towards Predicting the Relative Aggregation Propensity of Amyloidogenic Peptides: Aβ(1-42)”, Nathaniel J. Zbacnik, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2020, 109: 624-632.

“Shape Characterization of Subvisible Particles using Dynamic Imaging Analysis”, Roman Mathaes, Mark Cornell Manning, Gerhard Winter, Ahmed Besheer, Julia Engert, and Glenn A. Wilson, J. Pharm. Sci. 2020, 109: 375-279.

“Denaturation and Aggregation of Interferon-τ in Aqueous Solution”, Ryan R. Manning, Ryan E. Holcomb, Auria A. Tellechea, Chelsey L. Gilley-Dunn, Nathaniel J. Zbacnik, Glenn A. Wilson, Ryan J. Krammes, Nathan S. Krammes, Gabriel J. Evans, Charles S. Henry, Mark Cornell Manning, Brian M. Murphy, Robert W. Payne, and Derrick S. Katayama, Pharm. Res. 2018, 35: article 137.

“High Throughput Detection of Deamidation Using S-(5’-adenosyl)-L-homocysteine Hydrolase and a Fluorogenic Reagent”, Brian M. Murphy, Tarik Ozumerzifon, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Biomed. Analysis 2018, 156: 323-327.

“Rational Design of Liquid Formulations of Proteins”, Mark Cornell Manning, Jun Liu, Tiansheng Li, and Ryan E. Holcomb, Adv. Protein Chem. Struct. Biol. 2018, 112: 1-59.

“Current Status of Analytical Techniques for Characterization of Protein Stability”, Sanket Patke, Joshua M. Stillahn, and Mark Cornell Manning, Biopharma Asia 2018, 6(1): 26+.

“Role of Buffers in Protein Formulations”, Teddy J. Zbacnik, Ryan E. Holcomb, Derrick S. Katayama, Brian M. Murphy, Robert W. Payne, Richard C. Coccaro, Gabriel J. Evans, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, J. Pharm. Sci. 2017, 106: 713-733.

“Stability of Lyophilized Teriparatide, PTH(1-34) After Reconstitution”, Gene Merutka, Brian M. Murphy, Glenn A. Wilson, James E. Matsuura, Charles S. Henry, and Mark Cornell Manning, Eur. J. Pharm. Biopharm. 2016, 99: 84-93.

“Comparability of Higher Order Structure in Proteins: Chemometric Analysis of Second Derivative Amide I Fourier Transform Infrared (FTIR) Spectra”, Gregory Stockdale, Brian M. Murphy, Jennifer D’Antonio, Mark Cornell Manning, and Wasfi A. Al-Azzam, J. Pharm. Sci. 2015, 104(1): 25-33.

“Review of Orthogonal Methods to Size Exclusion Chromatography (SEC) for Quantitation and Characterization of Protein Aggregates”, Ryan R. Manning, Ryan E. Holcomb, Glenn A. Wilson, Charles S. Henry, and Mark Cornell Manning, BioPharm Intl. 2014, 27(11): 32+.

“Use of the Amide II Infrared Band of Proteins for Secondary Structure Determination and Comparability of Higher Order Structure”, Brian M. Murphy, Jennifer D’Antonio, Mark Cornell Manning, and Wasfi A. Al-Azzam, Curr. Pharm. Biotechnol. 2014, 15(9): 880-889.

“Protein Instability during Shipping: Implications for Basic and Applied Research”, Brian M. Murphy, Spencer Swarts, Barbara M. Mueller, Peter van der Geer, Mark Cornell Manning, and Mark Fitchmun, Nature Methods 2013, 10: 278-279.

“Flow Imaging: Moving Towards Best Practices for Subvisible Particle Quantitation in Protein Products”, Glenn A. Wilson and Mark Cornell Manning, J. Pharm. Sci. 2013, 102: 1133-1134.

“Effects of Solution Conditions on Methionine Oxidation in Albinterferon alfa-2b and the Role of Oxidation in its Conformation and Aggregation”, Danny K. Chou, Rajesh Krishnamurthy, Mark Cornell Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2013, 102: 660-673.

“Stability of Lyophilized Sucrose Formulations of an IgG1: Subvisible Particle Formation”, Janice M. Davis, Ning Zhang, Robert W. Payne, Brian M. Murphy, Ahmad M. Abdul-Fattah, James E. Matsuura, Alan C. Herman and Mark Cornell Manning, Pharm. Dev. Technol. 2013, in press.

“Characterization of Protein Higher Order Structure using Vibrational Circular Dichroism (VCD) Spectroscopy”, Radhika Nagarkar, Brian M. Murphy, Xiaotong Xu, Mark Cornell Manning, and Wasfi A. Al-Azzam, Curr. Pharm. Biotechnol. 2013, 14: 199-208.

“Physical Stability of Albinterferon alfa-2b in Aqueous Solution- Effects of Conformational Stability and Colloidal Stability on Aggregation”, Danny K. Chou, Rajesh Krishnamurthy, Mark Cornell Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2012, 101: 2702-2719.

“Comparability of Protein Therapeutics: Quantitative Comparison of Second Derivative Amide I Infrared Spectra”, Jennifer D’Antonio, Brian M. Murphy, Mark Cornell Manning, and Wasfi A. Al-Azzam, J. Pharm. Sci. 2012, 101: 2025-2033.

“Structure, Stability, and Mobility of a Lyophilized IgG1 Monoclonal Antibody as Determined by Second Derivative Infrared Spectroscopy”, Brian M. Murphy, Ning Zhang, Robert W. Payne, Janice M. Davis, Ahmad M. Abdul-Fattah, James E. Matsuura, Alan C. Herman and Mark Cornell Manning, J. Pharm. Sci. 2012, 101: 81-91.

“Product Development Issues with PEGylated Proteins”, Robert W. Payne, Brian M. Murphy, and Mark Cornell Manning, Pharm. Dev. Technol. 2011, 16: 423-440.

“Aggregation of Recombinant Human Botulinum Protein Antigen Serotype C in Varying Solution Conditions: Implications of Conformational Stability on Aggregation Kinetics”, Shujun Bai, Mark Cornell Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2011, 100: 836-848.

“Chemical Instability in Peptide and Protein Pharmaceuticals”, Elizabeth M. Topp, Lei Zhang, Hong Zhao, Robert W. Payne, Gabriel J. Evans, and Mark Cornell Manning, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 41-67.

“Protein Stability during Bioprocessing”, Mark Cornell Manning, Gabriel J. Evans, and Robert W. Payne, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 605-624.

“Prediction of Aggregation Propensity from Primary Sequence Information”, Mark Cornell Manning, Gabriel J. Evans, Cody M. Van Pelt, and Robert W. Payne, in: Formulation and Process Development Strategies for Manufacturing of a Biopharmaceutical (F. Jameel and S. Hershenson, Eds.), 2010, 329-347.

“Stability of Protein Pharmaceuticals: An Update”, Mark Cornell Manning, Danny K. Chou, Brian M. Murphy, Robert W. Payne, and Derrick S. Katayama, Pharm. Res. 2010, 27: 544-575.

“Multivariate Analysis of the Sequence Dependence of Asparagine Deamidation Rates in Peptides”, Andrew A. Kosky, Vasumathi Dharmavaram, Gayathri Ratnaswamy, and Mark Cornell Manning, Pharmaceutical Res. 2009, 26: 2417-2428.

“Peptide Formulation: Challenges and Strategies”, Robert W. Payne and Mark Cornell Manning, Innov. Pharm. Technol. Spring 2009, 28: 64-68.

“Ability of Two All Natural Products, Nootkatone and Carvacrol, to Supress Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) in a Lyme Disease Endemic Area of New Jersey”, Marc C. Dolan, Robert A. Jordan, Terry L. Schulze, Christopher J. Schulze, Mark Cornell Manning, Daniel Ruffolo, Jason P. Schmidt, Joseph Piesman, and Joseph J. Karchesy, J. Econ. Entomol. 2009, 102: 2316-2324.

“Impact of Bulking Agents on the Stability of a Lyophilized Monoclonal Antibody”, Jeffrey D. Meyer, Rajiv Nayar, and Mark Cornell Manning, Eur. J. Pharm. Sci. 2009, 38: 29-38.

“Stability of Human Serum Albumin during Bioprocessing. Aggregation during Terminal Heat Treatment”, Jen-Jen Lin, Jeffrey D. Meyer, John F. Carpenter, and Mark Cornell Manning, Intl. J. Biol. Macromol. 2009, 45: 91-96.

“Mixing Properties of Lyophilized Protein Systems: A Spectroscopic and Calorimetric Study”, Derrick S. Katayama, John F. Carpenter, Kevin P. Menard, Mark Cornell Manning, and Theodore W. Randolph, J. Pharm. Sci. 2009, 98: 2954-2969.

“Characterization of Amorphous Solids with Weak Glass Transitions Using High Ramp Rate Differential Scanning Calorimetry”, Derrick S. Katayama, John F. Carpenter, Mark Cornell Manning, Theodore W. Randolph, Peter Setlow, and Kevin P. Menard, J. Pharm. Sci. 2008, 97: 1013-1024.

“Second Virial Coefficient Determination of a Therapeutic Peptide by Self-Interaction Chromatography”, Robert W. Payne, Rajiv Nayar, Ralph Tarantino, Sam Del Terzo, John Moschera, Jie Di, David Heilmann, Brian Bray, Mark Cornell Manning, and Charles S. Henry, Biopolymers (Peptide Science) 2006, 84: 527-533.

“Solution Behavior of a Novel Biopharmaceutical Drug Candidate: A Gonadotropin-Toxin Conjugate”, Derrick S. Katayama, Paul Jarosz, and Mark Cornell Manning, Drug Dev. Ind. Pharm. 2006, 32: 1175-1184.

“Effects of Buffer Species on the Thermally Induced Aggregation of Interferon-tau”, Derrick S. Katayama, Rajiv Nayar, Danny K. Chou, Joseph J. Valente, Julianne Cooper, Charles S. Henry, David G. Vander Velde, Lorelie Villarete, C.P. Liu, and Mark Cornell Manning, J. Pharm. Sci. 2006, 95: 1212-1226.

“Towards the Systematic Use of Virial Coefficient Studies for Evaluating Cosolvent-Induced Stabilization and Solubilization of Proteins”, Joseph J. Valente, Kusum Verma, Mark Cornell Manning, W. William Wilson, and Charles S. Henry, Biophys. J. 2005, 89: 4211-4218.

“Feasibility of Tissue Plasminogen Activator Formulated for Pulmonary Delivery”, John S. Dunn, Rajiv Nayar, Jackie Campos, Brooks M. Hybertson, Y. Zhou, Mark Cornell Manning, John E. Repine, and Kathleen A. Stringer, Pharm. Res. 2005, 22: 1700-1707.
“Microparticle-based Lung Delivery of INH Decreases INH Metabolism and Targets Alveolar Macrophages”, Huiyu Zhou, Yangling Zhang, Danielle L. Biggs, Mark C. Manning, Theodore W. Randolph, Uwe Christians, Brooks M. Hybertson, and Ka-yun Ng, J. Controlled Rel. 2005, 107: 288-299.

“Solution Behavior of a Novel Type 1 Interferon, Interferon-tau“, Derrick S. Katayama, Rajiv Nayar, Danny K. Chou, Jackie Campos, Julianne Cooper, David G. Vander Velde, Lorelie Villarete, C.P. Liu, and Mark Cornell Manning, J. Pharm. Sci. 2005, 94: 2703-2713.

“Noninvasive Determination of Protein Conformation in the Solid State Using Near Infrared (NIR) Spectroscopy”, Shujun Bai, Rajiv Nayar, John F. Carpenter, and Mark Cornell Manning, J. Pharm. Sci. 2005, 94: 2030-2038.

“Colloidal Behavior of Proteins: Effects of the Second Virial Coefficient on Solubility, Crystallization, and Aggregation of Proteins in Aqueous Solution”, Joseph J. Valente, Robert W. Payne, Mark Cornell Manning, W. William Wilson and Charles S. Henry, Current Pharm. Biotechnol. 2005, 6: 427-436.

“Use of Infrared Spectroscopy to Monitor Protein Structure and Stability”, Mark Cornell Manning, Expert Rev. Proteomics 2005, 2 (5): 731-743.

“Effects of Tween 20 and Tween 80 on the Stability of Albutropin during Agitation”, Danny K. Chou, Rajesh Krishnamurthy, Theodore W. Randolph, John F. Carpenter, and Mark Cornell Manning, J. Pharm. Sci. 2005, 94: 1368-1381.

“Heterogeneous Nucleation-Controlled Particulate Formation of Recombinant Human Platelet-Activating Factor Acetylhydrolase in Pharmaceutical Formulation”, Eva Y. Chi, Joachim Weickmann, John F. Carpenter, Mark C. Manning, and Theodore W. Randolph, J. Pharm. Sci. 2005, 94: 256-274.

“Self-Interaction Chromatography for Screening”, Charles S. Henry, Robert W. Payne, Joseph J. Valente, and Mark Cornell Manning, Genetic Eng. News 2005, 25 (8): 62-63.

“Protease Autolysis in Heavy-Duty Detergent Formulations: Effects of Thermodynamic Stabilizers and Protease Inhibitors” Michael R. Stoner, Douglas A. Dale, Peter J. Gualfetti, Todd Becker, Mark C. Manning, John F. Carpenter, and Theodore W. Randolph, Enzyme Microb. Technol. 2004, 34: 114-125.

“Mechanism for Benzyl Alcohol-Induced Aggregation of Recombinant Interleukin-1 Receptor Antagonist in Aqueous Solution”, Ye Zhang, Shouvik Roy, LaToya S. Jones, Sampathkumar Krishnan, Bruce A. Kerwin, Byeong S. Chang, Mark C. Manning, Theodore W. Randolph, and John F. Carpenter, J. Pharm. Sci. 2004, 93: 3076-3089.

“Degradation Kinetics of High Molecular Weight Poly(L-lactide) Microspheres and Release Mechanism of Lipid-DNA Complexes”, Mayank M. Patel, Micelle G. Zeles, Mark C. Manning, Theodore W. Randolph, and Thomas J. Anchordoquy, J. Pharm. Sci. 2004, 93: 2573-2584.

“Retrospective Statistical Analysis of Lyophilized Formulations of Progenipoietin using PLS. Determination of the Critical Parameters for Long-term Storage Stability”, Derrick S. Katayama, Carol F. Kirchhoff, Carrie M. Elliott, Robert E. Johnson, Jeffry Borgmeyer, Barrett R. Thiele, David L. Zeng, Hong Qi, John D. Ludwig, and Mark C. Manning, J. Pharm. Sci. 2004, 93: 2609-2623.

“Quantification of Glycine Crystallinity by Near-Infrared Spectroscopy”, Shu Jun Bai, Meena Rani, Raj Suryanarayanan, John F. Carpenter, Rajiv Nayar, and Mark C. Manning, J. Pharm. Sci. 2004, 93: 2439-2447.

“Improved Potency of Cisplatin by Hydrophobic Ion Pairing”, Lixin Feng, Alexandra De Lille, Vicky J. Jameson, Leia Smith, William S. Dernell, and Mark C. Manning, Cancer Chemother. Pharmacol. 2004, 54: 441-448.

“Infrared Spectroscopic Studies of Protein Formulations Containing Glycine”, Jeffrey D. Meyer, Shu Jun Bai, Meena Rani, Raj Suryanarayanan, Rajiv Nayar, John F. Carpenter, and Mark C. Manning, J. Pharm. Sci. 2004, 93: 1359-1366.

“Effects of KBr Disk Formation on the Infrared Spectra of Model Proteins”, Jeffrey D. Meyer, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 2004, 93, 496-506.

“In vitro and in vivo Evaluation of the Effects of PLA Microparticle Crystallinity on Cellular Response”, Danielle L. Biggs, Corinne S. Lengsfeld, Brooks M. Hybertson, Ka-yun Ng, Mark C. Manning, and Theodore W. Randolph, J. Controlled Rel. 2003, 92: 147-161.

“Effects of Sucrose on Conformational Equilibria and Fluctuations within the Native State Ensemble of Proteins”, Yong-sung Kim, LaToya S. Jones, Aichun Dong, Brent S. Kendrick, Byeong S. Chang, Mark C. Manning, Theodore W. Randolph and John F. Carpenter, Protein Sci. 2003, 12, 1252-1261.

“High-Throughput Formulation of Biopharmaceutical Products in the Postgenomic Age”, Shu Jun Bai, Derrick S. Katayama, Danny K.C. Chou, Thomas J. Anchordoquy, Rajiv Nayar, and Mark C. Manning, Genomic/Proteomic Technology, October 2003, 28F-28H.

“The Use of Fluorescence Resonance Energy Transfer to Monitor Dynamic Changes of Lipid-DNA Interactions during Lipoplex Formation”, Ye Zhang, William Garzon-Rodriguez, Mark C. Manning, and Thomas J. Anchordoquy, Biochim. Biophys. Acta 2003, 1614, 182-192.

“Congo Red Populates Partially Unfolded States of an Amyloidogenic Protein to Enhance Aggregation and Amyloid Fibril Formation”, Yong-Sung Kim, Theodore W. Randolph, Mark C. Manning, Fred J. Stevens, and John F. Carpenter, J. Biol. Chem. 2003, 278, 10842-10850.

“Lipid Unsaturation Determines the Interaction of AFP Type I with Model Membranes during Thermotropic Phase Transitions”, Melanie M. Tomczak, László Vigh, Jeffrey D. Meyer, Mark C. Manning, Dirk. K. Hincha, and John H. Crowe, Cryobiology 2002, 45, 135-142.

"Characterization of the Solution Conformations of Leuprolide Acetate", Jeffrey D. Meyer, Mark C. Manning, and David G. Vander Velde, J. Peptide Res.  2002, 60, 159-168.

“Dissolution and Partitioning Behavior of Hydrophobic Ion Paired Complexes”, Douglas Pitera, Corinne S. Lengsfeld, Mark C. Manning, and Theodore W. Randolph, Pharm. Res. 2002, 19, 1572-1576.

“Aggregation of Granulocyte Colony Stimulating Factor under Physiological Conditions: Characterization and Thermodynamic Inhibition”, Sampathkumar Krishnan, Eva Y. Chi, Jonathan N. Webb, Byeong S. Chang, Daxian Shan, Merrill Goldenberg, Mark C. Manning, Theodore W. Randolph, and John F. Carpenter, Biochemistry 2002, 41, 6422-6431.

“The Stability Factor: Importance in Formulation Development”, Rajesh Krishnamurthy and Mark C. Manning, Curr. Pharm. Biotechnol. 2002, 3, 361-371.

“Long-Term Storage of Proteins”, John F. Carpenter, Mark C. Manning, and Theodore W. Randolph, Current Protocols in Protein Science 2002, 4.6.1-4.6.6.

“Ion Pairing of Isoniazid Using a Prodrug Approach”, Huiyu Zhou, Corinne S. Lengsfeld, David J. Claffey, James A. Ruth, Brooks A. Hybertson, Theodore W. Randolph, Ka-yun Ng, and Mark C. Manning, J. Pharm. Sci. 2002, 91, 1502-1511.

"Evaluation of Cisplatin in Combination with a Biological Response Modifier in a Murine Mammary Carcinoma Model", Emanuela, Morello, William S. Dernell, Charles A. Kuntz, Mary Lafferty, Ann Nelson, John H. Brekke, Craig H. Mallinckrodt, Stephen J. Withrow, and Mark C. Manning, Cancer Investigations 2002, 20, 480-489.

“Encapsulating DNA within Biodegradable Polymeric Microspheres”, Corinne S. Lengsfeld, Mark C. Manning, and Theodore W. Randolph, Curr. Pharm. Biotechnol. 2002, 3, 227-235.

"Effect of Conformation on the Chemical Stability of Polypeptides", Jeffrey D. Meyer, Bert Ho, and Mark C. Manning, in Pharmaceutical Biotechnology, Volume 13, John F. Carpenter and Mark C. Manning, Eds., Kluwer Academic/Plenum Press, New York, 2002, 85-107.

"High Throughput Formulation: New Strategies for Developing Stable Protein Formulations", Rajiv Nayar and Mark C. Manning, in Pharmaceutical Biotechnology, Volume 13, John F. Carpenter and Mark C. Manning, Eds., Kluwer Academic/Plenum Press, New York, 2002, 177-198.

"Rational Design of Stable Protein Formulations: Theory and Practice", Volume 13 of Pharmaceutical Biotechnology, John F. Carpenter and Mark C. Manning, Editors, Plenum Press, New York, 2002.

“High Throughput Drug Development: Meeting the Coming Challenges”, Rajiv Nayar and Mark C. Manning, BioPharm Feb. 2002, 25-32.

“Controlling Deamidation Rates in a Model Peptide: Effects of Temperature, Peptide Concentration, and Additives”, Lewis P. Stratton, R. Michael Kelly, Jared Rowe, Jesse E. Shively, D. David Smith, John F. Carpenter, and Mark C. Manning, J. Pharm. Sci. 2001, 90, 2141-2148.

“The Effect of Including Tween 20 and/or Sucrose in the Lyophilization and Reconstitution Medium of a Lyophilized Antibody”, LaToya S. Jones, Theodore W. Randolph, Ulrich Kohnert, Apollon Papadimitriou, Gerhard Winter, Marie-Luise Hagmann, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 2001, 90, 1466-1477.

"In Vivo Evaluation of Antibiotic-Impregnated Beads in a Rat Osteomyelitis Model", W.S. Dernell, C. Gentry-Weeks, M. C. Manning, B.E. Powers, M. Lafferty, C.A. Kuntz, J.E. Shively, R.F. Falk, J.D. Meyer, T.W. Randolph, and S.J. Withrow, J. Bioactive Compatible Polym. 2001, 16, 235-252.

"In Vivo Evaluation of Gentamicin-Impregnated Polylactic Acid Beads Implanted in Sheep", W.S. Dernell, S.J. Withrow, M.C. Manning, C.A. Kuntz, R. Dewell, F.B. Garry, B.E. Powers, J.E. Shively, R.F. Falk, and T.W. Randolph, J. Bioactive Compatible Polym.  2001, 16, 119-135.

“Counteracting Effects of Renal Solutes in Amyloid Fibril Formation by Immunoglobulin Light Chains”, Yong-sung Kim, Stephen P. Cape, Eva Chi, Rosemarie Raffen, Priscilla Wilkins-Stevens, Fred J. Stevens, Mark C. Manning, Theodore W. Randolph, Alan Solomon, and John F. Carpenter, J. Biol. Chem. 2001, 276, 1626-1633.

"Comparative FT-IR and CD Spectroscopic Analysis of a1-Proteinase Inhibitor and Ovalbumin in Aqueous Solution", Aichun Dong, Jeffrey D. Meyer, Mark C. Manning, Jerry L. Brown, and John F. Carpenter, Arch. Biochem. Biophys. 2000, 383, 148-155.

"Effect of Zinc-Binding and Precipitation on Structures of Recombinant Human Growth Hormone and Nerve Growth Factor", Tzung-Horng Yang, Jeffrey L. Cleland, Jeffrey D. Meyer, LaToya S. Jones, Theodore W. Randolph, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 2000, 89, 1480-1485.

"Stability of Human Serum Albumin during Bioprocessing. Denaturation and Aggregation during Processing of Albumin Paste", Jen-Jen Lin, Jeffrey D. Meyer, John F. Carpenter, and Mark C. Manning, Pharmaceutical Res. 2000, 17, 391-396.

"Intracavitary Slow Release Paclitaxel Polymer in a Rodent Model of Mammary Carcinoma", V.S. Bregazzi, W.S. Dernell, D.J. Huber, R. Schochet, M. Lafferty, G.K. Oglivie, S.J. Withrow, B.E. Powers, and M. Manning, J. Bioactive Compatible Polym. 2000, 15, 85-88.

"Thermodynamic Modulation of Light Chain Amyloid Fibril Formation", Yong-sung Kim, Jonathan S. Wall, Jeffrey Meyer, Charles Murphy, Theodore W. Randolph, Mark C. Manning, and John F. Carpenter, J. Biol. Chem. 2000, 275, 1570-1573.

"Long Chain Arginine Esters: A New Class of Biocompatible Cationic Detergents", David J. Claffey, Jeffrey D. Meyer, Robert Beauvais, Tessa Brandt, Eli Shefter, David J. Kroll, James A. Ruth, and Mark C. Manning, Biochem. Cell Biol. 2000, 78, 59-65.

"Optimizing Storage Stability of Lyophilized Actin with Dextran/Disaccharide Mixtures", S.D. Allison, A. Williams, K. Middleton, T.W. Randolph, M.C. Manning and J.F. Carpenter, J. Pharm. Sci. 2000, 89, 199-214.

"Domain Structure of gpNu1, a Phage Lambda DNA Packaging Protein: Identification of Self-Association and gpA-Interactive Domains", Qin Yang, Nancy Berton, Mark C. Manning, and Carlos E. Catalano, Biochemistry 1999, 38, 14238-14247.

"Tyrosine, Phenylalanine, and Disulfide Contributions to the Circular Dichroism of Proteins: CD Spectra of Wild Type and Mutant Bovine Pancreatic Trypsin Inhibitor", Narasimha Sreerama, Mark C. Manning, Michael E. Powers, Jian-Xin Zhang, David P. Goldenberg, and Robert W. Woody, Biochemistry 1999, 38, 10814-10822.

"In Vitro Release Kinetics of Gentamycin Sulfate from a Hyaluronate Gel Delivery System for the Treatment of Peripheral Vestibular Disease", R. Michael Kelly, Jeffrey D. Meyer, James E. Matsuura, Eli Shefter, Michael J. Hart, Daniel C. Malone, and Mark C. Manning, Drug Dev. Ind. Pharm. 1999, 25, 15-20.

"Inhibition of Stress-Induced Aggregation in Protein Therapeutics", John F. Carpenter, Brent S. Kendrick, Byeong S. Chang, Mark C. Manning, and Theodore W. Randolph, in Methods in Enzymology, R. Wetzel, ed., Academic Press 1999, 309, 236-255.

"Binding of Pyridoxal 5'-Phosphate to the Heme Protein Cystathione β-Synthase", Vladamir Kery, Loelle Poneleit, Jeffrey D. Meyer, Mark C. Manning, and Jan P. Kraus, Biochemistry 1999, 38, 2716-2724.

"Cloning, Expression and Characterization of a DNA Binding Domain of gpNu1, a Phage Lambda DNA Packaging Protein", Qin Yang, Tonny de Beer, Liping Woods, Jeffrey D. Meyer, Mark C. Manning, Michael Overduin, and Carlos Enrique Catalano, Biochemistry 1999, 38, 465-477.

"Tween Protects Recombinant Human Growth Hormone against Agitation-Induced Damage via Hydrophobic Interactions", Narendra B. Bam, Jeffrey L. Cleland, Mark C. Manning, John F. Carpenter, Robert F. Kelley, and Theordore W. Randolph, J. Pharm. Sci. 1998, 87, 1554-1559.

"Effect of Tween 20 on Freeze-Thawing and Agitation-Induced Aggregation of Recombinant Human Factor XIII", Lotte Kreilgaard, LaToya S. Jones, Theodore W. Randolph, Sven Frokjaer, James M. Flink, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 1998, 87, 1597-1603.

"Secondary Structure of Antifreeze Proteins from Overwintering Larvae of the Beetle Dendroides canadensis", Ning Li, Brent S. Kendrick, Mark C. Manning, John F. Carpenter, and John G. Duman, Arch Biochem. Biophys. 1998, 360, 25-32.

"Effects of Drying Methods and Additives on Structure and Function of Actin: Mechanisms of Dehydration-Induced Damage and Its Inhibition", S. Dean Allison, Theodore W. Randolph, Mark C. Manning, Kim Middleton, Ashley Davis, and John F. Carpenter, Arch. Biochem. Biophys. 1998, 358, 171-181.

"Intermolecular b-Sheet Results from Trifluoroethanol-Induced Non-Native a-Helical Structure in β-Sheet Predominant Proteins: Infrared and Circular Dichroism Spectroscopic Study", Aichun Dong, James E. Matsuura, Mark C. Manning, and John F. Carpenter, Arch. Biochem. Biophys. 1998, 355, 275-281.

"Aggregation of Recombinant Human Interferon-gamma: Kinetics and Structural Transitions", Brent S. Kendrick, Jeffrey L. Cleland, Xanthe Lam, Tue Nguyen, Theodore W. Randolph, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 1998, 87, 1069-1076.

"Preparation and In Vitro Characterization of Gentamycin-Impregnated Biodegradable Beads Suitable for Treatment of Osteomyelitis", Jeffrey D. Meyer, Richard F. Falk, R. Michael Kelly, Jesse E. Shively, Steven J. Withrow, William S. Dernell, Theodore W. Randolph, and Mark C. Manning, J. Pharm. Sci. 1998, 87, 1149-1154.

"Alveolar Macrophage Cell Line is Not Activated by Exposure to Polymeric Microspheres", Ka-yun Ng, Kathleen A. Stringer,  Zoe Cohen, Robert Serravo, Bin Tian, Jeffrey D. Meyer, Richard Falk, Theodore W. Randolph, Mark C. Manning, and David C. Thompson, Int. J. Pharm. 1998, 170, 41-50.

"The Phage Lambda Terminase Enzyme. 2. Refolding of the gpNu1 Subunit from the Detergent-Denatured and Guanidinium Hydrochloride-Denatured State Yields Different Oligomerization States and Altered Protein Stabilities", Jeffrey D. Meyer, Adrienne Hanagan, Mark C. Manning, and Carlos Enrique Catalano, Int. J. Biol. Macromol. 1998, 23, 37-48.

"The Phage Lambda Terminase Enzyme. 1. Reconstitution of the Holoenzyme from the Individual Subunits Enhances the Thermal Stability of the Small Subunit", Jeffrey D. Meyer, A. Hanagan, Mark C. Manning, and Carlos Enrique Catalano, Int. J. Biol. Macromol. 1998, 23, 27-36.

"Hydrophobic Ion Pairing: Altering the Solubility of Biomolecules", Jeffrey D. Meyer and Mark C. Manning, Pharmaceutical Res. 1998, 15, 188-193.

"Hydrophobic Ion Pairing of Subtilisin BPN' Results in Structural Stabilization and Increased Activity in Isooctane", Brent S. Kendrick, Jeffrey D. Meyer, James E. Matsuura, John F. Carpenter, and Mark C. Manning, Arch. Biochem. Biophys. 1997, 347, 113-118.

"Use of Circular Dichroism Spectroscopy in Determining the Conformation of a Monoclonal Antibody Prior to its Incorporation in an Immunoliposome" Ka-yun Ng, Limin Zhao, Jeffrey D. Meyer, Lana Grauer-Kittman, and Mark C. Manning, J. Pharm. Biomed. Anal. 1997, 16, 507-513.

"Spectroscopic Study of Secondary Structure and Thermal Denaturation of Recombinant Human Factor XIII in Aqueous Solution", Aichun Dong, Lotte Krielgaard, Brent S. Kendrick, James Matsuura, Mark C. Manning, and John F. Carpenter, Arch. Biochem. Biophys. 1997, 347, 213-220.

"Preferential Exclusion of Sucrose from Recombinant Human Interleukin-1 Receptor Antagonist: Role of Restricted Conformational Mobility and Compaction of Native State", Brent S. Kendrick, Byeong S. Chang, Tsutomu Arakawa, Ted Randolph, Mark C. Manning, and John F. Carpenter, Proc. Natl. Acad. Sci. USA 1997, 94, 11917-11922.

"Structure-Activity Studies on Position 14 of Human-a-Calcitonin Gene-Related Peptide (h-a-CGRP)", Jianzhong Li, James E. Matsuura, Thomas E. Adrian, Mark C. Manning, and D. David Smith, J. Med. Chem. 1997, 40, 3071-3076.

"Drug Delivery Matrix Containing Native Protein Precipitates Suspended in a Poloxamer 407 Gel", Lewis P. Stratton, Aichun Dong, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 1997, 86, 1006-1010.

"Secondary Structure of Human Cystathione-β-Synthase in Aqueous Solution: Effect of Ligands and Proteolytic Truncation", Aichun Dong, Vladamir Kery, James Matsuura, Mark C. Manning, Jan P. Kraus, and John F. Carpenter, Arch. Biochem. Biophys. 1997, 344, 125-132.

"Investigation of the aT244M Mutation in the Alpha Subunit of Paracoccus dentrificans Electron Transfer Flavoprotein", Kurt J. Griffin, Timothy M. Dwyer, Mark C. Manning, Jeffrey D. Meyer, John F. Carpenter, and Frank E. Frerman, Biochemistry 1997, 36, 4194-4202.

"Controlled Release of Ionic Pharmaceuticals from Poly (L-lactide) Microspheres Produced by Precipitation with a Compressed Antisolvent", Richard F. Falk, Theodore W. Randolph, Jeffrey D. Meyer, R. Michael Kelly, and Mark C. Manning, J. Controlled Rel. 1997, 44, 77-85.

"Dual Modes of Activation of Mitogen-Activated Protein Kinase Kinase 1 as Revealed by Kinetic Analysis and Mutagenesis", Sam Mansour, Julian M. Candia, James E. Matsuura, Mark C. Manning, and Natalie G. Ahn, Biochemistry 1996, 35, 15529-15536.

"Effect of Secondary Structure on the Activity of Enzymes Suspended in Nonaqueous Solvents", Aichun Dong, Jeffrey D. Meyer, Brent S. Kendrick, Mark C. Manning, and John F. Carpenter, Arch. Biochem. Biophys. 1996, 334, 406-414.

"Thermal Stability of Low Molecular Weight Urokinase during Heat Treatment. III. Effects of Salts, Sugars, and Additional Purification", Thomas M. Foster, Jonathon J. Dormish, Uday Narahari, Jeffrey D. Meyer, Michael Vrkljan, Jack Henkin, William R. Porter, John F. Carpenter, and Mark C. Manning, Int. J. Pharm. 1996, 134, 193-202.

"Generation of Soluble and Active Subtilisin in Organic Solvents Via Hydrophobic Ion Pairing", Jeffrey D. Meyer, Brent S. Kendrick, James E. Matsuura, James A. Ruth, Philip N. Bryan, and Mark C. Manning, Int. J. Peptide Protein Res. 1996, 47, 177-181.

"Quantitation of Area of Overlap between Second Derivative Amide I Infrared Spectra to Determine Structural Similarity of a Protein in Different States", Brent S. Kendrick, Aichun Dong, S. Dean Allison, Mark C. Manning, and John F. Carpenter, J. Pharm. Sci. 1996, 85, 155-158.

"Infrared and Circular Dichroism Spectroscopic Characterization of Structural Differences in β-Lactoglobulin Genetic Variants", Aichun Dong, James Matsuura, S. Dean Allison, Eric Chrisman, Mark C. Manning, and John F. Carpenter, Biochemistry 1996, 35, 1450-1457.

"Sequence Analysis of Fibrolase, a Fibrinolytic Metalloproteinase from Agkistrodon contortrix contortrix", Mark C. Manning, Toxicon 1995, 33, 1189-1200.

"Solution Behavior of a-Chymotrypsin Dissolved in Nonpolar Solvents Via Hydrophobic Ion Pairing", Jeffrey D. Meyer, James E. Matsuura, Brent S. Kendrick, Emily S. Evans, Gabriel J. Evans, and Mark C. Manning, Biopolymers 1995, 35, 451-456.

"Approaches for Increasing the Solution Stability of Proteins", Mark C. Manning, James E. Matsuura, Brent S. Kendrick, Jeffrey D. Meyer, Jonathon J. Dormish, Michael Vrkljan, James R. Ruth, John F. Carpenter, and Eli Shefter, Biotechnol. Bioeng. 1995, 48, 506-512.

"Two-, Three-, and Four-Dimensional Nuclear Magnetic Resonance Spectroscopy of Protein Pharmaceuticals", David G. Vander Velde, James Matsuura, and Mark C. Manning, in Pharmaceutical Biotechnology, Volume 7, James Herron, Wim Jiskoot, and Daan J.A. Crommelin, Eds., Plenum Press, New York, 1995, 179-218.

"Heat-Induced Gelation of β-Lactoglobulin: A Study of the Secondary and Tertiary Structure as Followed by Circular Dichroism Spectroscopy", James E. Matsuura and Mark C. Manning, J. Agric. Food Chem. 1994, 42, 1650-1656.

"Selective Precipitation of Interleukin-4 Using Hydrophobic Ion Pairing: A Method for Improved Analysis of Proteins Formulated with Large Excesses of Human Serum Albumin", Jeffrey D. Meyer, James E. Matsuura, James A. Ruth, Eli Shefter, Suman T. Patel, James Bausch, Eugene McGonigle, and Mark C. Manning, Pharmaceutical Res. 1994, 11, 1492-1495.

"Thermal Stability of Low Molecular Weight Urokinase during Heat Treatment. II. Effects of Polymeric Additives", Michael Vrkljan, Michael E. Powers, Thomas M. Foster, Jack Henkin, William R. Porter, John F. Carpenter, and Mark C. Manning, Pharmaceutical Res. 1994, 11, 1004-1008.

"Solution Behavior of Leuprolide Acetate, a LHRH Agonist, as Determined by Circular Dichroism Spectroscopy", Michael E. Powers, Akwete Adjei, Mou-Ying Fu Lu, and Mark C. Manning, Int. J. Pharm. 1994, 108, 49-56.

"Delta-Sleep Inducing Peptide: Solution Conformational Studies of a Membrane-Permeable Peptide", Ronda A. Gray, David G. Vander Velde, Carl J. Burke, Mark C. Manning, Gautam Sanyal, C. Russell Middaugh, and Ronald T. Borchardt, Biochemistry 1994, 33, 1323-1331.

"Circular Dichroism in the Analysis of Protein Structure", John F. Towell, III and Mark C. Manning, in Analytical Applications of Circular Dichroism, N. Purdie and H.G. Brittain, Eds., Elsevier, 1994, 175-205.

"Thermal Stability of Low Molecular Weight Urokinase During Heat Treatment. I. Effects of Protein Concentration, pH and Ionic Strength", William R. Porter, Harold Staack, Karol Brandt, and Mark C. Manning, Thrombosis Research 1993, 71, 265-279.

"Enhanced Solubility of Proteins and Peptides in Nonpolar Solvents Through Hydrophobic Ion Pairing", Michael E. Powers, James Matsuura, James Brassell, Mark C. Manning, and Eli Shefter, Biopolymers  1993, 33, 927-932.

"Conformation of Human Calcitonin Gene-Related Peptide(8-37) in Aqueous Solution as Determined by Circular Dichroism Spectroscopy", James Matsuura and Mark C. Manning, J. Pharm. Biomed. Anal.  1993, 11, 89-93.

"Fibrolase, a Fibrinolytic Protein from Snake Venom", Denise Pretzer, Brenda Schulteis, Chris Smith, David G. Vander Velde, James W. Mitchell, and Mark C. Manning, in Pharmaceutical Biotechnology, Volume 5, Y. J. Wang and R. Pearlman, Eds., Plenum Press, 1993, 287-314.

"Structure and Stability of Insulin Dissolved in 1-Octanol", James Matsuura, Michael E. Powers, Mark C. Manning, and Eli Shefter, J. Am. Chem. Soc. 1993, 115, 1261-1264.

"The Use of Computer Aided Modeling to Understand Peptide Transport", R.A. Gray, D.G. Vander Velde, R.T. Borchardt, C.J. Burke, C.R. Middaugh, and M.C. Manning,  Chemical Design Automation News  1992, 7, 1, 36-39, 41.

"Effect of Zinc Binding on the Structure and Stability of Fibrolase, a Fibrinolytic Protein from Snake Venom", Denise Pretzer, Brenda S. Schulteis, Christopher D. Smith, David G. Vander Velde, James W. Mitchell, and Mark C. Manning, Pharmaceutical Res. 1992, 9, 870-877.

"Stability of Protein Pharmaceuticals: in vivo Pathways of Degradation and Strategies for Protein Stabilization", Volume 3 of Pharmaceutical Biotechnology, Tim J. Ahern and Mark C. Manning, Editors, Plenum Press, New York, 1992.

"Stability of Protein Pharmaceuticals: Chemical and Physical Pathways of Protein Degradation", Volume 2 of Pharmaceutical Biotechnology, Tim J. Ahern and Mark C. Manning, Editors, Plenum Press, New York, 1992.

"Pharmaceutical Biotechnology. Protein Stability and Its Enhancement- An Overview", Tim J. Ahern and Mark C. Manning, in Pharmaceutical Biotechnology, Volume 2, Tim J. Ahern and Mark C. Manning, Eds., Plenum Press, New York, 1992, pp. ix-xvii.

"Protein Structure and Stability Assessment by Circular Dichroism Spectroscopy", Mark C. Manning,  in Biocatalyst Design for Stability and Specificity, Michael E. Himmel and George Georgiou, Eds., ACS Symposium Series 1992, 516, 33-52.

"The Helix-Coil Transition in Heterogenous Peptides with Specific Side Chain Interactions", Paul M. Gans, Pingchiang C. Lyu, Mark C. Manning, Robert W. Woody, and Neville R. Kallenbach, Biopolymers  1991, 31, 1605-1614.

"Stability of the Thrombolytic Protein Fibrolase. Effect of Temperature and pH on Activity and Conformation", Denise Pretzer, Brenda S. Schulteis, Christopher D. Smith, David G. Vander Velde, James W. Mitchell, and Mark C. Manning, Pharmaceutical Res.  1991, 8, 1103-1112.

"Protein Chemistry: A Graduate Course in Pharmaceutical Biotechnology at the University of Kansas", Mark C. Manning and James W. Mitchell, Am. J. Pharm. Educ.  1991, 55, 52-55.

"Theoretical CD Calculations of Polypeptide Helices.  Determination of the Important Electronic and Geometric Factors", Mark C. Manning and Robert W. Woody, Biopolymers  1991, 31, 569-586.

"Underlying Assumptions in the Estimation of Secondary Structure Content in Proteins by Circular Dichroism Spectroscopy- A Critical Review", Mark C. Manning, J. Pharm. Biomed. Anal.  1989, 7, 1103-1119.

"Conformation of the Alpha Form of Calcitonin Gene-Related Peptide (CGRP) in Aqueous Solution as Determined by Circular Dichroism Spectroscopy", Mark C. Manning, Biochem. Biophys. Res. Commun. 1989, 160, 388-392.

“Comparison of the Secondary Structures of Human Class-I and Class-II MHC Antigens by FTIR and CD Spectroscopy”, Joan C. Gorga, Aichun Dong, Mark C. Manning, Robert W. Woody, Winslow S. Caughey, and J.L. Strominger, in Protein Structure and Engineering (NATO Advanced Science Institute Series, Series A, Life Sciences), Volume 183, O. Jardetzky, Ed., Plenum Press, 1989, pp. 355-365.

"Stability of Protein Pharmaceuticals", Mark C. Manning, Kamlesh Patel, and Ronald T. Borchardt, Pharmaceutical Res.  1989, 6, 903-918.

"Contribution of Aromatic Side Chains to the Circular Dichroism of Basic Bovine Pancreatic Trypsin Inhibitor (BPTI): A Theoretical Study", Mark C. Manning and Robert W. Woody, Biochemistry  1989, 28, 8609-8613.

"Comparison of the Secondary Structures of Human Class I and Class II MHC Antigens by IR and CD Spectroscopy", Joan C. Gorga, Aichun Dong, Mark C. Manning, Robert W. Woody, Winslow S. Caughey, and Jack L. Strominger, Proc. Natl. Acad. Sci. USA 1989, 86, 2321-2325.

"Circular Dichroism Studies of Distorted α Helices, Twisted β Sheets, and β Turns", Mark C. Manning, Mali Illangasekare, and Robert W. Woody, Biophys. Chem. 1988, 31, 77-86.

"Synthesis and Reactions of Dinuclear Palladium Complexes Containing Methyls and Hydride on Adjacent Palladium Centers: Reductive Elimination and Carbonylation Reactions", S.J. Young, B. Kellenberger, Joseph H. Reibenspies, S.E. Himmel, M. Manning, O.P. Anderson, and J.K. Stille, J. Am. Chem. Soc. 1988, 110, 5744-5753.

"Preparation and Characterization of Palladium(II)- and Platinum(II)-OTeF5 Complexes", Mark R. Colsman, Mark C. Manning, Oren P. Anderson, and Steven H. Strauss, Inorg. Chem. 1987, 26, 3958-3960.

"Theoretical Determination of the Circular Dichroism of Proteins Containing Closely-Packed Antiparallel β Sheets", Mark C. Manning and Robert W. Woody, Biopolymers 1987, 26, 1731-1752.

"Molecular Orbital Calculations on the Oligopeptides Netropsin, Distamycin, and Related Compounds", Mark C. Manning and Robert W. Woody, Biopolymers 1986, 25, 2065-2082.

"Spectroscopic and Theoretical Studies on Binuclear Molybdenum (II) Carboxylates", Mark C. Manning,  Gary F. Holland, Donald E. Ellis, and William C. Trogler, J. Phys. Chem. 1983, 87,  3083-3088.

"Electronic Absorption and Emission Spectra of Complexes Containing Dichromium, Dimolybdenum, and Ditungsten Quadruple Bonds", Mark C. Manning and William C. Trogler, J. Am. Chem. Soc. 1983, 105, 5311-5320.

"The Electronic Structure of V(CO)6.  Why It Is Black", Gary F. Holland, Mark C. Manning, Donald E. Ellis, and William C. Trogler, J. Am. Chem. Soc. 1983, 105, 2308-2314.

"Electronic Absorption Spectra of Tetra-µ-acetatodimolybdenum in Low Temperature Matrices" Mark C. Manning and William C. Trogler, Inorg. Chem. 1982, 21, 2797-2800.

"Xa Calculations and Spectroscopic Studies of Triruthenium and Triosmium  Dodecacarbonyl", Bernard Delley, Mark C. Manning, Donald E. Ellis, Joseph Berkowitz, and William C. Trogler, Inorg. Chem. 1982, 21, 2247-2253.

"Electronic Structure of Transition Metal Cluster Complexes", Mark C. Manning and William C. Trogler, Coord. Chem. Rev. 1981, 38, 89-138.

"Reduction of Metal Carbonyl Compounds Using Alkali Metal Carbides", Mark C. Manning and William C. Trogler, Inorg. Chim. Acta 1981, 50, 247-250.