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Issue Summary

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October 2008
High Concentration Formulations of IL-1ra…1
High Concentration Formulations of IL-1ra…1
Stability of Polysorbates
Computational Study on Proteolysis
Mannitol Polymorphism in Lyo Products
Raman Detection of Insulin Aggregation
Prediction of Protein Solubility
Thermally-Induced Gelation: Salt Effects
MAb Adsorption and Chromatography
Protein Flexibility and Stability
Self-Buffering MAb Formulations
Annealing and Mobility in Glasses
Macromolecular Crowding and Aggregation
Reversible Protein Precipitation
IR Studies of Adsorbed Proteins

September 2008
Concentration Effects on Aggregation
Asp and Asn Racemization
Oxidation and Aggregation of a Light Chain
Thermodynamic vs. Kinetic Stability
Stabilization of Spray-Dried IgG1
Additive Effects of Chaotropes on Azurin
Molecular Crowding Effects on Stability
Structure of the Denatured State
Structural Changes during Fibril Formation
Aggregation Kinetics by DSC
Thermal Stability and Heat Capacity
Multiple Aggregation Pathways in a Peptide
Photostability of Cys Residues
Supercritical Fluid Drying of Proteins

August 2008
Glycosylation and Protein Folding
Prediction of Aggregation-Prone Regions
Fragmentation of a Monoclonal Antibody
Met Oxidation of a Monoclonal Antibody
Heterogeneity of MAbs
Empirical Phase Diagram of a Peptide
Cosolvent Effects on Protein Functionality
Enzyme Stability in Ethanol Mixtures
Macromolecular Crowding and Stability
Multiprobe Denaturation Studies
Cold Denaturation and Alcohol Effects
Cyclodextrin Stabilization of a Peptide
Protein-Water Interaction in Silk Fibroin
Protein Stability during Fill/Finish

July 2008
Review on Polysorbates
Stable Flu Vaccine Powders
Denaturation Studies with Mass Spec
Stabilization by Charged Solutes
Salts and Immunoglobulin LC Stability
Sequence and Stability of λ6 Light Chains
Correlation of Stability and Amyloidosis
Amyloid Growth using a Microbalance
Fluorescence Correlation Spectroscopy
Online Dye Detection of IgG aggregates
Conformational Stability and Fibrillogenesis
Amorphous Lyophilized Salts
Lyophilized Growth Hormone
Protein-Protein Interactions

June 2008
Freeze-Thaw Stability of an IgG2
IgG Denaturation using an Optical Sensor
Protein Denaturation
O-Glycosylation and Protein Stability
Aggregation of α-Chymotrypsin
Met Oxidation of Fc Region of a IgG1
B Values and Self-Association
Solid-State Fluorescence of Proteins
Excluded Solutes and α-lactalbumin
Stability of Protein G Mutants
Raman Spectroscopy of Proteins
Electrostatics and Conformational Stability
Asp-Asp Motifs in MAbs

May 2008
Trehalose and Spray-Dried Enzyme
Variable Domains and IgG1 Stability
Protein Hydration
Microplate-Based Method for Unfolding
Ultrasound Velocity Studies of Aggregation
Secondary Structure Content by CD
Protein Stability in Ice
Hydrophobic Effect on Protein Stability
Excipient Selection for Spray-dried Proteins
Sucrose and Surface Adsorption

April 2008
Flexibility and Stability of an IgG1
Quality by Design: Lyophilization
Glycosylation Effects on Protein Stability
Pulsed Light and Protein Stability
Moisture-Induced Aggregation
Polyols and Denaturation of Antibodies
Sulfate and Endostatin Denaturation
Secondary Structure Content from CD
Denaturation by Urea and Temperature
Aggregation Kinetics for Neuroproteins
Amyloid Nucleation via Agitation
ANS Binding to IL-1ra
Cold Shock Proteins

March 2008
Factors in Conformational Stability
Denaturation of Proteins
Biopolymers and Freeze-Dried Stability
Aggregation Resistance in Antibodies
Peptide Stability in Nonaqueous Solvents
Cysteinylation of a Monoclonal Antibody
Stability of a IgG4
Moisture Content of Lyophilisates by NIR
Frozen State Stability of an Enzyme
Mixing Effects on Intramoelcular Disulfides
Filtration of Polysorbates
TMAO and Protein Denaturation
Protein Hydration

February 2008
Solutes and Protein Aggregation
Glycation of a IgG2 MAb
DSC and Protein Aggregation
Monitoring Protein Denaturation
Amyloid Folding (review)
Spray Drying of Whey Proteins
Supercritical Fluid Drying of IgG
Dried Human Growth Hormone
Formulation of a Hydrophobic Cytokine
SAXS of Pegylated Hemoglobin
Thiol Oxidation in Proteins
Thiols and Amyloid Formation
Disulfide Bond in the IgG1 CH3 Domain

January 2008
Biosimilars: Comparability
Shipping Frozen Protein Samples
High Concentration Formulations of MAbs
Pegylation of Proteins (Special Issue
Sequence Effects on Aggregation
Tween 80 and Protein Stability
Photostability of Milk Proteins
Photostability of Antibodies
Protein Stabilization with Gelatins
Supercritical Fluid Drying of Proteins
Aggregation Kinetics
PAT and Protein Stability
Denaturation at the Air-Water Interface
β-Sheets and Fibril Formation

December 2007
VCD and Fibril Formation
Fluorescence Detection of Aggregates
Protein-Quantum Dot Conjugates
Stability of Fusion Proteins
Improving the Solubility of a Protease
Freezing Damage of Proteins
Protein-Surfactant Interactions
Second Virial Coefficients of Proteins
Formulation Screening with DSC
Formulation of Hydrophobic Proteins


November 2007
Water and Protein Thermal Stability
Shear and Antibody Stability
Water Content and Solid State Stability
Met Oxidation in a MAb
Hinge Region Hydrolysis in a MAb
TMAO as a Protein Stabilizer
Metal Binding in hGH
Metal Binding and Thermostability
Disaccharides as Lyoprotectants
Stabilization of a Cytokine with HSA
IR of Hydrated Proteins
Mass Spec Analysis of IgG Glycation
pH Stabilization of Proteins
Cyclodextrins and a Lyophilized Protein
Raman Spectroscopy of Proteins
Screening for Protein Antioxidants


October 2007
Hydration of Proteins
Pressure-Induced Refolding of Proteins
Protein Structure by NIR
Gamma-Irradiation of Insulin
Solubility and Viscosity of Fish Proteins
Effect of Salts on Protein Stability
Cold Denaturation and Surface Stability
Cyclic Imide Formation
Kinetics of Aggregation
Antibodies at Surfaces
Protein Aggregation by DLS
LC-MS of a MAb
Protein Formulation Review


September 2007
Radiolabeled Antibodies
Analysis of Amyloid Formation
Contaminants in Pre-Filled Syringes
SLS of Highly Concentrated Solutions
Drying of Proteins
Water Desorption from Proteins
Pegylated Growth Factor
Aggregation of Lyophilized Proteins
Zeta Potential of Antibodies
Kinetics of the Helix/Coil Transition
Chemical Stability of MAbs


August 2007
Immunogenicity of Proteins
Modeling Protein Aggregation
Quantitation of Aggregation by AUC
Modeling Aggregation Kinetics
Colloidal Stability of a MAb
Measuring Insoluble Protein Aggregates
Stabilization of a Lyophilized Protein
Reconstitution of Lyophilized Proteins
Pressure-Induced Denaturation
Sequence Analysis of Fibril Formers
Protein Stability during HIC
Fibril Formation in Whey Protein
Stability of a Dried MAb


July 2007
Measuring Protein Aggregation
Succinimide Formation in an IgG2
Salt Effects on Protein-Surface Interactions
Structural Stabilizers and Asp Isomerization
Metal Ions and Peptide Stability
Container Compatibility
Solid-State Protein Structure and Dynamics
Protein Aggregation
Protein-Dextran Interactions
Raman Spectroscopy of Fibrils
Urea and Protein Denaturation
More on Protein Denaturation
Deamidation and Biological Activity


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