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Issue Summary


 
Here are the topics covered in the most recent issues of Staying Current: Formulation of Biopharmaceuticals: Please select the option below, if you'd like to subscribe.



January 2011

Amyloidogenesis of IgG Light Chains
Met Oxidation of MAbs
Effect of Oxidation on Protein Structure
Hemoglobin Structure in Electric Fields
Deamidation and Electric Fields
Leachable from a Protein in I.V. Bags
Glycation of Immunoglobulin G
Methylglyoxal Reaction with ∝-Crystallin
CD Spectra of Peptides in Films
Mass Spectrometry of Amyloid
Interfacial Packing of Proteins on Surfaces
Shear Forces and Unfolding of vWF
Dental Formulations of bFGF
Deamidation and Solubility of Hordein
Trp Residue and Staph. Nuclease Stability
Rigidity and Thermostability
Amyloidogenic Intermediates
DNA Formulation Development
Prediction of Disulfides
Conformation of Disulfides
Patterns around Disulfides
Hydration and Acid Unfolding
Thermostabilization of an Esterase
Thermal Behavior of ß-Lactamase
Specificity of Fibril Formation
Light Chain Amyloidosis
Aß(1-42) Fibril Stability
IAPP Fibril Formation
Instability and Bioprocessing
Cofactor Stabilization of bR
Ethanol-Induced Aggregation
IDP Fusion Proteins
Aggregation of Myosin Subfragments
Cys Sulfenic Acid and Disulfide Bonds
GnHCl-Induced Aggregation
Acid-Induced Aggregation of MAbs

February 2011
Subvisible Particles in an IgG2 Preparation
Adsorption of MAbs to Glass
Studying MAb Aggregation with AFM
H-D Exchange Studies of Fibril Formation
Nucleation and Fibril Polymorphism
Removing Insulin Microaggregates
Enzyme in Polyurethane Foam
Oxidation and Conformational Stability (2)
pKa Values in the Unfolded State
Mobility in the Glassy State
Solid State Stability and Glycosylation
Primary Drying Rates and Protein Stability
Coated Microneedles and Protein Stability
Influenza Vaccine and Microneedles
Vaccines and Aluminum Salt Adjuvants
HTS of Aluminum-Adjuvanted Antigens
Immunogenicity of Protein Therapeutics
Ligand-Induced Changes in Unfolding
Degradation of Polysorbates
High Pressure Unfolding of Proteins
Urea and Dry Globule States of Proteins
Phase Separation in Lyophilisates
Nebulization of Dornase AlfA
Crowding and Protein-Protein Binding
Interactions of Crowding Agents

March 2011
Carrier Systems for Polypeptides
Injectable Thermosetting Hydrogel
Conjugation of Peptides to Macromolecules
Thermoresponsive Gels & Protein Delivery
Nanoporous Microparticles from Sugars
Surface Tension and Protein Stability
Polyols and Stability of G-CSF
Aggregation of Amelogenin
Protein Aggregation
Premolten Globule State in Cytochrome c
New Sugar-Based Surfactants
Ion Exchange Chromatography of MAbs
Stability of ∝-Amylases upon Glycation
Effect of Salts on Protein Viscosity
SDS-Induced Denaturation of Lipase
Surfactants and ∝-Lactalbumin
Oxidation of Dairy Proteins
MS Methods for Monitoring Oxidation
RNase A Oligomer Formation
Neutron Scattering of Sugar-Lysozyme
ß-CDs in Lyophilized Formulations
Sucrose-Polymer Lyo Formulations
Aggregation of a Bot Protein Antigen
Protein Adsorption to Biopolymers
Stability of Allergens during Processing
High Hydrostatic Pressure Refolding
Field-Flow Fractionation
Phase Transitions in Folded Proteins
Fibroin Hydrogels of MAb Delivery
Proteins in Silica Matrices

April 2011

Correction (Hoehne et al.)
Shear Effects on Protein Stability
m-Cresol-Induced Aggregation
siRNA Delivery to the Lung
Flow Cytometry and Silicone Oil
Flow Cytometry and Subvisible Particles
bis-ANS and Thermally Stressed IgG1
High Throughput Solubility Screening
Ficin Denaturation
High-throughput Screening of Formulations
Selective Accumulation of Ions on Proteins
Alternative IgG4-Fc Structures
Comparability Studies of IgG1 MAbs
Dansyl-PEGs as Peptide Stabilizers
Asp-Asp Isomerization and Racemization
Disaccharides and a Lyophilized Enzyme
Freeze-Thaw Stability of MCP-1
Enzymatic Fragmentation of a MAb
Removal of MAb Aggregates using CHT
Stability of a Proline-Stabilized IgG Product
Aggregation and Complement Activation
Thermostability and Salt Bridge Formation
Prediction pf Protein Binding Regions
GlycoPEGylation of Factor VIIa
Protein Stabilization by Zinc Ion
Disulfides and Fibril Formation
Aggregation of ⋎D Crystallin
Crowding Effects on Protein Structure
Crowding Effects on Amyloid Formation 12
Destabilization of Protein by Osmolytes
Monitoring Aggregation with NMR
Aggregation Pathways in IAPP
Aggregation of ApoA-I Mutants
Analysis of Aß Fibrils by CE
Properties of Lyophilized Cakes by NIR
Detecting Phase Separation by Raman
Moisture-Induced Aggregation of TT

May 2011
Assessing Protein Aggregates
Modeling Amyloid Formation
Aggregation of ⋎S-Crystallin
Chemical Modification and Stabilization
Osmolytes and Denaturants
Effect of Osmolytes on a Model Peptide
Saccharides and Protein Stability
Hydration and Peptide Stabilization
Immunogenicity Assessment
Frozen Storage of a Monoclonal Antibody
Primary Drying Effects on Proteins
Effect of Metal Ions on Aß Fibrillation
Two Distinct Aggregation Pathways for Aß
Repeated Seeding of Aß Fibrillation
Aß Intermediates by NMR
Whey Protein-Surfactant Interactions
Thermal Aggregation of Wine Proteins
UF/DF of Monoclonal Antibodies
Nanoparticle Detection of Aggregation
Pharmacopeial Standards
PEGylation of Insulin
Ice-Induced Damage: Membrane Protein
Interactions and Phase Separation
NIR as a PAT Tool

June 2011

Degradation of Polysorbates
Aggregation of IgG1 at low pH (2)
High Throughput Screening of MAbs
Protein-Protein Interactions in MAbs
Fluorescence Single Particle Tracking
Protein-Surfactant Interactions
Current Uses of Trehalose
Effect of Syringe Surfaces on Proteins
Immunogenicity and Aggregation
Insulin Fibrillation and Teflon
Litrate Adducts of Oxytocin
Oxytocin Stabilization by Metals and Citrate
Injectable Microspheres of IFN-?2b
Respirable Nanoparticles of DNase I
Glucagon-Loaded Nanospheres
Respirable Protein Powder by Spray Drying
PTH(1-34) Powders for Inhalation
Resveratrol Inhibits Oligomer Formation
Polyoxometalates Inhibit Fibrillation
Aggregation of PEGylated Insulin
Site-Specific Glycation of a MAb
Antibody Analysis of HSA Glycation
F-T Stability by H/D Exchange
Comparability using H/D Exchange
Thermal Inactivation of Lipase
Thermal Stability of Tyrosinase
Hydrophobic Interactions and Stability
Dynamics of Lysozyme-Water Mixtures
Solvent of Protein Dynamics
Aggregation of BSA
Reversible Dissociation of Fibrils
Non-Arrhenius Model of Aggregation
Container Selection for Peptide Work
Transdermal Delivery of Proteins

July 2011

Platform Formulation of Proteins
Cosolutes and Protein Stability
Polyols Stabilization of Proteins
Rational Vaccine Formulation Development
Small Angle Scattering and Aggregation
WAXS and Insulin Denaturation
CE-MS of Proteins
Salting-In of Proteins
Arginine and Protein Aggregation
Aromatic Side Chains and Aß Fibrillation
Premolten and Molten Globules of Cyt-c
Nanoparticle Inhibition of Aß Fibrillation
New Analytical Methods for Proteins
Thermal Stress Testing of Etanercept
Tuning Up Proteins
Physical Stability of Oxidized Calcitonin
Racemization in the Hinge Region of IgG1
Freezing Step in Lyophilization
Effect of Freezing on Buffers
Analysis of Mannitol with Raman and NIR
Lyophilization of DNA Polyplexes
Hydrophobic Hydration and Denaturation
Engineering Protein Stability
Comparing SEC and AF4
Fibril Polymorphism
Denaturation of ∝-Crystallin
Ions and the Air/Water Interface
Revisiting Ramachandran Plots

August 2011
Delivery of Angiogenic Growth Factors
Lyophilization of PEG-hGH
Lyophilization Cycle Optimization
HIP and Protein Encapsulation into PLGA
Microemulsions and Transdermal Delivery
Delivery of Peptide-Based Vaccines
AF4 Analysis of Proteins and Particles
IR Detection of Met Oxidation
Conformational Flexibility and Fibrillation
Aggregation of ß-Lactoglobulin
Stabilization of HRP
Stabilization of a MAb with Basic a.a.’s
Oxidation of Trp in CDR of a IgG1
PEGylation and BA-Induced Aggregation
Effect of CH2 Conformational Stability
Insulin Aggregation during Agitation
Fragmentation of IgG1 MAbs
Nanoparticle Delivery of siRNA
O-Glycosylation and Stability of IFN-∝2b
Oral Delivery of Insulin
Protein Adsorption and Drug Delivery
HIC Analysis of an Oxidized IgG1
CE Analysis of Disulfide Scrambling
Fibrillation of Myoglobin Mutants
Prediction of Aggregation Propensity
Dry Heat Induced Aggregation of WPI
Intranasal Immunization
GAGs Promote Light Chain Fibrillation
QbD and Biopharmaceutical Development
Unfolding/Aggregation of Lysozyme
High Pressure and Protein Flexibility
Metal Ions and Aggregation of HSA
Formulation of a Live Vaccine
Polyol Stabilization of Proteins
Polyol Hydrophobicity and a.a. Solubility

September 2011
High Throughput Screening for Stabilizers
Classification of Protein Aggregates
Chemical Modifications of Aggregates
Viscosity of High Concentration BSA
Effect of Sugars on the Viscosity of MAbs
MAb Aggregation at low pH
MAb Aggregation during Manufacturing
MAb Compatibility with Pre-filled Syringes
High Fidelity Peptide Mapping
Glycosylation Status by Raman
Surfactant Interactions and Aggregation
Aggregates of WPI and ?-Lactoglobulin
Monitoring Protein Unfolding by CE
Stability of Repackaged MAbs
Setting Guidelines for Biosimilars
Biosimilar EPOs in Thailand
Stabilization of Endoglucanse by EDTA
Flexibility and Protein Stability
Dry Powder Aerosols for Gene Delivery
Moisture-Induced Aggregation
Detection of Amyloidogenic Proteins
Aggregation of Monoclonal Antibodies
Oxidation and Thermal Aggregation
Arg and Lysozyme Aggregation
Non-Fibrillar Aggregation of ?-Synuclein
Heat-Induced Aggregation by MS
Thermal Stability Shift Analysis

October 2011
Deamidation Leads to Fibril Formation
Monitoring Glycation of IgG1
Chain Scission at Ser Residues
Shear Flow Effects on Proteins
Coulter Counting and Subvisible Particles
Nanoparticle Size Measurements
Taylor Dispersion Analysis for Sizing
Chiral Amyloid Superstructures
Suppression of Aggregation by Arg
Post-Production Aggregation of Proteins
Quantitation of Aggregation by SV-AUC
Predicting MAb Aggregation Rates
Thermal Precipitation Assay
Denaturation of Transketolase
Comparability Strategies for MAbs
Subvisible Particles during Filling
Effect of Alcohols on Hemoglobin Structure
Fibrillation of Insulin Analogs
Secondary Structure from Amide VI Bands
Stability-Indicating Assay for GM-CSF
Characterization of Radiolabeled MAbs
2-D Gels and MALDI-TOF of MAbs
Acetontrile-Induced Aggregation of IgGs
Radical-Induced Degradation of MAbs
Aggregation Detection with a Sensor
Minimizing Protein Surface Adsorption

November 2011
Lessons on Protein Stability
Stability of Lyophilized ß-Lactoglobulin
Sugar Crystallization in Lyophilisates
Drying of Invertase in Alginate Beads
Development of PEGylated Proteins
Stability of Small PEGylated Proteins
Measuring B22 Values using DLS
Opalescence Behavior of an IgG2
Comparability Assessment of Two MAbs
CD Spectroscopy of Proteins
IR Spectroscopy of Proteins
Salt Effects on Structure by IR Spectroscopy
Multidimensional Formulation
Effects of Interfaces and Leachables
Glass Particles as Adjuvants
Aggregation Hotspots near CDRs
Calcium Binding to FIX-Fc Fusion Protein
Effect of Ca on Polyol Stabilization
Degradation of PTH(1-34)
Novel Degradation of a PEGylated Protein
Stabilization of Calcitonin by Pluronic F68
Benzyl Alcohol and IL-1ra
Saccharides and Tg Values
Worldwide Biosimilar Development
Salt Bridges and Thermostability