INTRODUCTION TO THE STABILISATION AND
FORMULATION OF PROTEINS
OCTOBER 4-5, 2010
EUROPEAN CONTINUING EDUCTAION COLLEGE
LONDON, UK
COURSE OUTLINE
Introduction to Protein Structure and Physical Properties
Overview of Instability Issues with Proteins
• Chemical Instability
• Conformational Instability (unfolding)
• Colloidal Instability
• Interfacial Instability
Protein Aggregation
• Basic Aggregation Mechanisms
• Controlling Aggregation
• Quantifying Aggregation
Rational Development of Liquid Dosage Forms
• Formulation Strategy
• Excipient Selection
• Selection of Analytical Methods
Rational Development of Dried Dosage Forms
• Formulation Strategy
• Excipient Selection
Selection of Analytical Methods
