TENTATIVE SHORT COURSE SCHEDULE

August 11-13, 2008

Loveland, Colorado

DAY 1 (start at 9 AM, finish about 5 PM)

Introductions

Formulation Strategies

Introduction to Peptide and Proteins

Break

Chemical Stability of Polypeptides

Lunch

Protein Denaturation

Surface Behavior

Protein Solubility

Break

Protein Aggregation I

Protein Aggregation II

Protein Aggregation III

DAY 2 (start at 9 AM, finish about 5 PM)

Methods for Monitoring Aggregation

Liquid Formulation Strategies

Break

Excipient Choices for Liquid Formulations

Lunch

Analytical Methods for Liquid Formulations

High Concentration Formulations

Break

Lyophilized Formulation Development I

Lyophilized Formulation Development II

DAY 3 (start at 9 AM, finish about 3 PM)

Analytical Methods for Solid Dosage Forms

Excipient Choices for Solid Dosage Forms

Break

Group Exercise (critical evaluation of commercial formulations)

Lunch

Peptide Formulation

Stability during Bioprocessing

Packaging Issues for Biopharmaceuticals

Break/Conclusion of Course